A hypothesis is a liability A Research Paper by Itai Yanai & Martin Lercher genomebiology.biomedcentral.com There is a hidden cost to having a hypothesis. It arises from the relationship between night science and day science, the two very distinct modes of activity in which scientific ideas are generated and tested, respectively [1, 2]. With a hypothesis in hand, the impressive strengths of day science are unleashed, guiding us in designing tests, estimating parameters, and throwing out the hypothesis if it fails the tests. But when we analyze the results of an experiment, our mental focus on a specific hypothesis can prevent us from exploring other aspects of the data, effectively blinding us to new ideas. researchsciencediscovery
Design with courage Make a bold decision (that is controversial). Make a mistake (as a result of a bold decision). Challenge “conventional wisdom”. Challenge authority (that preaches conventional wisdom). Challenge hierarchy (that perpetuates conventional wisdom). Ignore the committee (and the need to converge). Decide who your clients are (and aren’t). Ignore clients that aren’t (especially those who pay the most). Cultivate clients if none exists (instead of compromising your design). Be a generalist (and ignore your job title). Be a specialist (who specializes in being a generalist). Design things from scratch (and build them yourself from scratch). Design things that no one wants (yet). Design freely (and think freely). Chuánqí Sun, The vanishing designer The boldest decisions design