A hypothesis is a liability A Research Paper by Itai Yanai & Martin Lercher genomebiology.biomedcentral.com There is a hidden cost to having a hypothesis. It arises from the relationship between night science and day science, the two very distinct modes of activity in which scientific ideas are generated and tested, respectively [1, 2]. With a hypothesis in hand, the impressive strengths of day science are unleashed, guiding us in designing tests, estimating parameters, and throwing out the hypothesis if it fails the tests. But when we analyze the results of an experiment, our mental focus on a specific hypothesis can prevent us from exploring other aspects of the data, effectively blinding us to new ideas. researchsciencediscovery
What's wrong with the rational model We Don’t Really Know the Goal When We Start We Usually Don’t Know the Decision Tree – We Discover It as We Go The Nodes Are Really Not Design Decisions, but Tentative Complete Designs The Goodness Function Cannot be Evaluated Incrementally The Desiderata and Their Weightings Keep Changing The Constraints Keep Changing Frederick P. Brooks, Jr., What's Wrong With This Model? Changing constraintsDeciding what to designThe situation talks back