Why Most Published Research Findings Are False A Research Paper by John P.A. Ioannidis journals.plos.org There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. researchsciencetruth
Wang tiles Wang tiles (Hao Wang, 1961) are a class of formal systems. They are modelled visually by square tiles with a color on each side. A set of such tiles is selected, and copies of the tiles are arranged side by side with matching colors, without rotating or reflecting them. The basic question about a set of Wang tiles is whether it can tile the plane or not, i.e., whether an entire infinite plane can be filled this way. The next question is whether this can be done in a periodic pattern. In 1966, Wang's student Robert Berger solved the problem in the negative. He proved that no algorithm for the problem can exist, by showing how to translate any Turing machine into a set of Wang tiles that tiles the plane if and only if the Turing machine does not halt. The undecidability of the halting problem then implies the undecidability of Wang's tiling problem. Wikipedia en.wikipedia.org Truchet TilesThe Tiling Patterns of Sebastien Truchet and the Topology of Structural Hierarchy mathalgorithms