Why Most Published Research Findings Are False A Research Paper by John P.A. Ioannidis journals.plos.org There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. researchsciencetruth
Some emptiness in us Whenever we encounter beauty we become aware, each time with a sense of shock and pleasure, faint though it may be, that some emptiness in us, not consciously felt but continually present, has been assuaged and fulfilled. We have a sudden high sense of completeness and harmony. David Pye, The Nature and Aesthetics of Design The Timeless Way of Building beauty