A hypothesis is a liability A Research Paper by Itai Yanai & Martin Lercher genomebiology.biomedcentral.com There is a hidden cost to having a hypothesis. It arises from the relationship between night science and day science, the two very distinct modes of activity in which scientific ideas are generated and tested, respectively [1, 2]. With a hypothesis in hand, the impressive strengths of day science are unleashed, guiding us in designing tests, estimating parameters, and throwing out the hypothesis if it fails the tests. But when we analyze the results of an experiment, our mental focus on a specific hypothesis can prevent us from exploring other aspects of the data, effectively blinding us to new ideas. researchsciencediscovery
Large combinatorial spaces For the theory of design is that general theory of search through large combinatorial spaces. Herbert Simon, The Sciences of the Artificial The rational model of design