Why Most Published Research Findings Are False A Research Paper by John P.A. Ioannidis journals.plos.org There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. researchsciencetruth
Wordless questioning The comparison of forms raises questions and drawing can be employed as a wordless questioning of form; the pencil seeks to extract from the complex whole some limited coherent pattern that our minds and eyes can grasp. The probing pencil is like the dissecting scalpel, seeking to expose relevant structures that may not be immediately obvious and are certainly hidden from the shadowy world of the camera lens. Jonathan Kingdon, In the Eye of the Beholder The World of the Sea