Why Most Published Research Findings Are False A Research Paper by John P.A. Ioannidis journals.plos.org There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. researchsciencetruth
Fermi Estimates and Dyson Designs An Article by Venkatesh Rao www.ribbonfarm.com A Fermi estimate is a quick-and-dirty solution to an arbitrary scientific or engineering analysis problem. Fermi estimation uses widely known numbers, readily observable phenomenology, basic physics equations, and a bunch of approximation techniques to arrive at rough answers that tend to be correct within an order of magnitude or so. The term is named for Enrico Fermi, who was famously good at this sort of thing. …It struck me that there is counterpart to this kind of thinking on the synthesis side, where you use similar techniques to arrive at a very rough design for a complex engineered artifact. I call such a design approach Dyson design, after the physicist Freeman Dyson, who was one of the best practitioners of it (not to be confused with inventor James Dyson, whose designs, ironically, are not Dyson designs). designphysics